期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 19, 期 8, 页码 1322-1325出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00170-12
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资金
- Danish International Development Agency (DANIDA)
- European & Developing Countries Clinical Trials Partnership (EDCTP HIV-VAC-RGB)
Hematology and biochemistry reference intervals have been derived from healthy, HIV-negative populations to guide clinical trials worldwide. However, it is less clear how such values may be applied to clinical trials involving HIV-infected individuals. We show that contradictory interpretations about patient recruitability are reached when applying African versus North American reference intervals to an HIV-1 cohort in Guinea-Bissau. These observations underscore the need to question non-African guidelines in the context of HIV intervention clinical trials in Africa.
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