期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 20, 期 2, 页码 302-305出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00605-12
关键词
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资金
- Los Alamos National Laboratory internal LDRD
- NIH [AI066924, AI078526, AI096040, AI080659]
- Ragon Institute of MGH
- Ragon Institute of MIT
- Ragon Institute of Harvard
Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides.
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