期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 19, 期 4, 页码 620-622出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00024-12
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资金
- Department for Environment, Food and Rural Affairs (DEFRA), United Kingdom
A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guerin (BCG)-vaccinated cattle when used as a skin test reagent for a DIVA test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.
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