期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 19, 期 2, 页码 284-287出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.05592-11
关键词
-
资金
- National Institutes of Health [P01 AI 57788, N01 AI 25465, P30 DK56336, M01 RR000188, T32 GM88129]
A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.
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