期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 19, 期 2, 页码 288-292出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.05583-11
关键词
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资金
- Pfizer, Inc.
- National Institutes of Health [AI076059, AI084113]
- Ontario HIV Treatment Network (OHTN)
T-cell responses to human endogenous retrovirus (HERV)K(HML-2) Gag and Env were mapped in HIV-1-infected subjects using 15mer peptides. Small peptide pools and high concentrations were used to maximize sensitivity. In the 23 subjects studied, only three bona fide HERV-K(HML-2)-specific responses were detected. At these high peptide concentrations, we detected false-positive responses, three of which were mapped to an HIV-1 Gag peptide contaminant. Thus, HERV-K(HML-2) Gag-and Env-specific T-cell responses are infrequently detected by 15mer peptide mapping.
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