期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 15, 期 3, 页码 582-584出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00427-07
关键词
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资金
- Public Health Service [R01 AI19990 and AI063382, R01 AI072052 and K08 AI060641]
- Bristol-Myers Squibb
- Burroughs Wellcome New Investigator Award
- Los Angeles Biomedical Research Institute Liu Young Investigator Award
- American Heart Association [0665154Y]
We are developing an anticandidal vaccine using the recombinant N terminus of Als3p (rAls3p-N). We report that although more rAls3p-N was bound by aluminum hydroxide diluted in saline than by aluminum hydroxide diluted in phosphate-buffered saline (PBS), its immunogenicity and efficacy were superior in PBS. Thus, protein binding, by itself, may not predict the efficacy of some vaccines with aluminum adjuvants.
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