期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 38, 期 9, 页码 632-637出版社
WILEY
DOI: 10.1111/j.1440-1681.2011.05571.x
关键词
ABCC1; drug response; genetic polymorphism; lung cancer; multidrug resistance; multidrug resistance-associated protein 1
资金
- National Science and Technology Major Project [2009ZX09304-003]
- National High-tech R&D Program of China (863 Program) [2009AA022704]
- National Natural Science Foundation of China [30572230, 30873089]
- Natural Science Foundation of Hunan Province of China [08JJ3058]
- Anhui Medical University [XJ201021]
- China Scholarship Council
- Ministry of Education of China
- Graduate Degree Thesis Innovation Foundation of Central South University [2009ybfz09]
- Hunan Province [CX2009B060]
1. In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1-induced multidrug resistance. The aim of the present study was to further investigate the association of this polymorphism with lung cancer susceptibility and chemotherapy response in a Chinese population. 2. A total of 77 lung cancer patients (54 men, 23 women) and 71 cancer-free controls (49 men, 22 women) were enrolled in the study. Genomic DNA was extracted from peripheral blood and all samples were genotyped using polymerase chain reaction-restriction fragment length polymorphism. 3. Individuals carrying the 723Gln (A) allele have a 3.4-fold increased risk (adjusted odds ratio (OR) 3.42; 95% confidence interval (CI) 1.29-9.06; P = 0.013) of lung cancer compared with wild-type individuals. Further stratified analysis indicated that older individuals (> 50 years) carrying the 723Gln (A) allele have the highest susceptibility to lung cancer (adjusted OR 4.10; 95% CI 1.25-13.48; P = 0.020). However, no substantial association was found between the Arg723Gln (2168G > A) polymorphism and chemotherapy response in Chinese lung cancer patients. 4. In conclusion, the Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population, especially in older people.
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