期刊
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
卷 36, 期 12, 页码 1139-1143出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1440-1681.2009.05275.x
关键词
exercise; inflammation; metabolism; muscle; peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha)
资金
- Swiss National Science Foundation [SNF PP00A-110746]
- Muscular Dystrophy Association USA (MDA)
- SwissLife 'Jubilaumsstiftung fur Volksgesundheit und medizinische Forschung'
- Swiss Society for Research on Muscle Diseases (SSEM)
- Swiss Diabetes Association
- Roche Research Foundation
- United Mitochondrial Disease Foundation (UMDF)
- Zurich Center for Integrative Human Physiology (ZIHP)
- Universities of Basel and Zurich
P>1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other lifestyle-associated diseases has increased in relevance in Western societies in the past 100 years. 2. Traditionally, fat tissue has been considered as the major source of pro-inflammatory secreted factors in these pathologies. However, in recent years the contribution of other tissues to disease-causing chronic inflammation has been increasingly appreciated. 3. Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) is one of the key regulatory factors in active skeletal muscle. Aberrant expression of PGC-1 alpha in inactive muscle fibres could be linked to a sedentary lifestyle, persistent systemic inflammation and a higher risk for many chronic diseases. Accordingly, modulation of PGC-1 alpha activity in skeletal muscle may have a broad range of therapeutic effects. Here, recent advances in the understanding of the role of muscle PGC-1 alpha in health and disease are reviewed.
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