期刊
CLINICAL AND EXPERIMENTAL NEPHROLOGY
卷 16, 期 5, 页码 722-729出版社
SPRINGER
DOI: 10.1007/s10157-012-0621-7
关键词
alpha-Klotho; CKD; CKD-MBD; FGF23
资金
- Daiwa Memorial foundation
- Japanese Kidney foundation
- Ministry of Education, Science, Culture and Sports of Japan
- Kochi Organization for Medical Reformation and Renewal
alpha-Klotho was first identified as an aging gene and was later shown to be a regulator of phosphate metabolism. Fibroblast growth factor 23 (FGF23) is the key regulator of phosphate metabolism. Serum levels of soluble alpha-Klotho in chronic kidney disease (CKD) patients have not previously been determined, especially in relation with FGF23 and creatinine levels. This study was designed to investigate whether serum soluble alpha-Klotho levels are modulated by renal function, age, and FGF23 level in CKD patients. This study is the first report on the utility of measuring soluble alpha-Klotho levels in human CKD. A total of 292 CKD patients were enrolled. Serum samples were collected, and FGF23 and soluble alpha-Klotho levels were measured using enzyme-linked immunosorbent assay kits. In addition, serum creatinine, hemoglobin, albumin, calcium, and phosphate levels were measured. Serum soluble alpha-Klotho levels were associated positively with estimated glomerular filtration rate (eGFR) (P < 0.0001) and inversely with serum creatinine level (P < 0.01). Interestingly, alpha-Klotho levels were significantly decreased in stage 2 CKD compared with stage 1 (P = 0.0001). Serum FGF23 levels were associated positively with serum creatinine and negatively with eGFR. FGF23 levels were significantly increased in stage 5 compared with stage 1 CKD. Soluble alpha-Klotho was associated inversely with log-transformed FGF23 level (P < 0.01). Our data indicate that soluble alpha-Klotho levels are significantly decreased in stage 2 CKD compared to stage 1, and not only in the advanced stages of the disease. Soluble alpha-Klotho may thus represent a new biomarker for the diagnosis of CKD, especially in the early stage.
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