期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 14, 期 2, 页码 133-140出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-013-0235-8
关键词
Circadian rhythm; Clock gene; Neuroendocrine-immune system; Metabolism
资金
- Italian Ministry of Health'' through Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit [RC1203ME46]
- IRCCS Scientific Institute
- Regional General Hospital Casa Sollievo della Sofferenza,'' Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy
Rhythmic variations with 24-h periodicity hallmark homeostatic regulation, metabolic processes and organ systems function, driven by a circadian timing system composed of central and peripheral oscillators. Recent reports suggest that disrupted circadian rhythmicity of physiology and behavior severely alters body homeostasis. Nuclear receptors and transcriptional regulators sense hormonal and metabolic cues and manage the rhythmic patterns of chromatin remodelling and gene expression, playing a key role in the cross talk between the circadian clock circuitry, the metabolic pathways and the organ systems. The alteration of this cross talk contributes to the pathophysiology of metabolic, degenerative, immune-related and neoplastic diseases.
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