期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 58, 期 11-12, 页码 442-444出版社
WILEY-BLACKWELL
DOI: 10.1002/jlcr.3348
关键词
meta-iodobenzylguanidine; destannylation; no-carrier-added; lyophilization
Radioiodinated meta-iodobenzylguanidine (MIBG) in high effective specific activity was prepared using 3-tributylstannylbenzylguanidine as the precursor. The labeling was carried out in aqueous solution with the insoluble and lyophilized precursor suspended in the solvent. Simply by filtration, the starting material and by-products were readily separated from the labeled solution. Less than 1.15 ppb tin has remained in the filtrate as determined by the atom fluorescence spectrometry. By this approach, high specific activity (3.4 GBq/mu mol) [I-131]MIBG was obtained in 72.3 +/- 3% (n = 3) radiochemical yield and 97.3 +/- 2% (n = 3) radiochemical purity. The whole preparation could be finished in less than 10 min. According to this method, a kit for the preparation of I-123-MIBG and I-131-MIBG is currently being developed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据