期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 175, 期 3, 页码 373-384出版社
WILEY
DOI: 10.1111/cei.12197
关键词
alemtuzumab; daclizumab; multiple sclerosis; natalizumab; rituximab
类别
资金
- Teva Pharmaceuticals
Monoclonal antibodies (mAbs) are used as therapeutics in a number of disciplines in medicine, such as oncology, rheumatology, gastroenterology, dermatology and transplant rejection prevention. Since the introduction and reintroduction of the anti-alpha4-integrin mAb natalizumab in 2004 and 2006, mAbs have gained relevance in the treatment of multiple sclerosis (MS). At present, numerous mAbs have been tested in clinical trials in relapsing-remitting MS, and in progressive forms of MS. One of the agents that might soon be approved for very active forms of relapsing-remitting MS is alemtuzumab, a humanized mAb against CD52. This review provides insights into clinical studies with the mAbs natalizumab, alemtuzumab, daclizumab, rituximab, ocrelizumab and ofatumumab.
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