期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 171, 期 1, 页码 20-29出版社
WILEY
DOI: 10.1111/j.1365-2249.2012.04627.x
关键词
arthritis; heat shock protein; mucosal; peptide; therapy
类别
Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen-specific immunotherapy for autoimmune diseases. Heat shock proteins are bystander antigens that are effective in peptide-specific immunotherapy in both experimental and human autoimmune disease. The efficacy of preventive peptide immunotherapy is increased by enhancing peptide-specific immune responses with proinflammatory agents. Combining peptide-specific immunotherapy with general suppression of inflammation may improve its therapeutic effect.
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