期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 163, 期 3, 页码 368-374出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2249.2010.04303.x
关键词
animal models; carbon monoxide-releasing molecules; CORM-A1; experimental allergic encephalomyelitis; SJL mice
类别
资金
- Alfama
We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na-2(BH3CO2); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.
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