期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 167, 期 1, 页码 59-66出版社
WILEY
DOI: 10.1111/j.1365-2249.2011.04503.x
关键词
basophil; desensitization; immunotherapy
类别
资金
- NIAID [R01 AI081845]
Allergen-specific immunotherapy is an effective clinical treatment for hypersensitivity to many allergens. Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of basophil activation as a biomarker of clinical outcomes. This review examines the evidence for different pathways of basophil modulation associated with various forms of immunotherapy. Better understanding the molecular mechanisms of basophil activation and desensitization and the relationship between suppression of these effector cells to clinical outcomes holds promise for further development and improvement in potential therapies for allergic diseases.
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