期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 165, 期 3, 页码 292-300出版社
WILEY
DOI: 10.1111/j.1365-2249.2011.04433.x
关键词
heat shock proteins; immunoregulation; inflammation
类别
资金
- Arthritis Research UK [18152] Funding Source: Medline
- Versus Arthritis [18152] Funding Source: Medline
- Versus Arthritis [18152] Funding Source: researchfish
The resolution of inflammation is central to the maintenance of good health and immune homeostasis. Recently, several intracellular stress proteins have been described as having extracellular properties that are anti-inflammatory or favour the resolution of inflammation. We propose that these molecules should be defined as resolution-associated molecular patterns (RAMPs). RAMPs are released at times of cellular stress and help to counterbalance the inflammatory effects of pathogen-associated (PAMPs) and damage-associated (DAMPs) molecular patterns. We propose that heat shock protein 10 (HSP10), alpha B-crystallin (alpha BC), HSP27 and binding immunoglobulin protein (BiP) should be considered founding members of the RAMP family. A greater understanding of RAMP biology may herald the development of novel immunotherapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据