期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 30, 期 5, 页码 509-513出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2015.30.5.509
关键词
Bronchopulmonary Dysplasia; Cell Transplantation; Mesenchymal Stem Cells; Infant; Premature
资金
- Korean Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [HI12C1821 (A121968)]
- Samsung Medical Center [F01140091]
- Korea Research Foundation grant from the National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology [NRF-2014R1A1A2056427]
Bronchopulmonary dysplasia (BPD), a chronic lung disease affecting very premature infants, is a major cause of mortality and long-term morbidities despite of current progress in neonatal intensive care medicine. Though there has not been any effective treatment or preventive strategy for BPD, recent stem cell research seems to support the assumption that stem cell therapy could be a promising and novel therapeutic modality for attenuating BPD severity. This review summarizes the recent advances in stem cell research for treating BPD. In particular, we focused on the preclinical data about stem cell transplantation to improve the lung injury using animal models of neonatal BPD. These translational research provided the data related with the safety issue, optimal type of stem cells, optimal timing, route, and dose of cell transplantation, and potency marker of cells as a therapeutic agent. Those are essential subjects for the approval and clinical translation. In addition, the successful phase I clinical trial results of stem cell therapies for BPD are also discussed.
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