期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 160, 期 3, 页码 403-410出版社
WILEY
DOI: 10.1111/j.1365-2249.2010.04106.x
关键词
allergoids; blocking antibodies; monophosphoryl lipid A (MPL); regulatory T -cells; ultra-short-course specific immunotherapy
类别
资金
- Allergy Therapeutics
- MSD
P>Specific immunotherapy (SIT) is a well-established and clinically effective treatment for allergic diseases. A pollen allergoid formulated with the T helper type 1 (Th1)-inducing adjuvant monophosphoryl lipid A (MPL) facilitates short-term SIT. Little is known about mechanisms of tolerance induction in this setting. In a prospective study, 34 patients allergic to grass pollen (25 male, nine female, median age 10 center dot 2 years) received a total of 44 SIT courses (20 in the first, 24 in the second) with MPL-adjuvanted pollen allergoids. Immunogenicity was measured by levels of specific immunoglobulin G (IgG(grass)) and IgG4(grass) by antibody blocking properties on basophil activation, and by induction of CD4+, CD25+ and forkhead box P3 (FoxP3+) regulatory T cells (T-reg). Specific IgG and IgG4 levels increased only slightly in the first year of SIT. In the second year these changes reached significance (P < 0 center dot 0001). In keeping with these findings, we were able to show an increase of T-reg cells and a decreased release of leukotrienes after the second year of treatment. In the first year of treatment we found little evidence for immunological changes. A significant antibody induction was seen only after the second course of SIT. Short-course immunotherapy with pollen allergoids formulated with the Th1-inducing adjuvant MPL needs at least two courses to establish tolerance.
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