期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 160, 期 1, 页码 48-57出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2249.2010.04122.x
关键词
anti-microbial; C; elegans; defence; infection; innate immunity
类别
资金
- NIAID NIH HHS [P01 AI044220] Funding Source: Medline
- NIDDK NIH HHS [P30 DK040561, P30 DK040561-15] Funding Source: Medline
P>The molecular mechanisms involved in host-microbe interactions during the initial stages of infection are poorly understood. The bacteria-eating nematode Caenorhabditis elegans provides an opportunity to dissect host-microbe interactions in the context of the whole organism, using powerful genomic, genetic and cell-biological tools. Because of the evolutionary conservation of ancient innate host defences and bacterial virulence mechanisms, studies in C. elegans hold great promise to shed light on defences in higher organisms, including mammals. Additionally, C. elegans pathogenesis models provide a platform for the identification of novel classes of anti-infective compounds with therapeutic value.
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