期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 160, 期 1, 页码 70-79出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2249.2010.04133.x
关键词
Darwinian medicine; dendritic cells; 'hygiene hypothesis'; 'old friends' hypothesis; T(reg)
类别
P>The current synthesis of the 'hygiene hypothesis' suggests that the recent increase in chronic inflammatory disorders is at least partly attributable to immunodysregulation resulting from lack of exposure to microorganisms that have evolved an essential role in the establishment of the immune system. This document provides a background for discussion of the following propositions. The essential role of these organisms is an example of 'evolved dependence'. The most relevant organisms are those that co-evolved with mammals, and already accompanied early hominids in the Paleolithic. More recently evolved 'childhood infections' are not likely to have evolved this role, and recent epidemiology supports this contention. This mechanism is interacting with other modern environmental changes that also lead to enhanced inflammatory responses [inappropriate diet, obesity, psychological stress, vitamin D deficiency, pollution (dioxins), etc.]. The range of chronic inflammatory disorders that is affected is potentially larger than usually assumed [allergies, autoimmunity, inflammatory bowel disease, but also vascular disease, some cancers, depression/anxiety (when accompanied by raised inflammatory cytokines), and perhaps neurodegenerative disorders and type 2 diabetes].
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据