期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 161, 期 1, 页码 142-150出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2249.2010.04164.x
关键词
cellular immunity; cytokines; intestinal helminths; multi-bacillary; Mycobacterium leprae
类别
P>Resistance to intracellular pathogens such as Mycobacterium leprae is dependent upon an effective T helper type 1 (Th1)-type immune response. On the other hand, intestinal helminths are known to subvert the host's immune response towards to either a Th2-type immune response or a regulatory T cell up-regulation, which may affect the host's ability to mount an effective response to mycobacteria. Here, we report a significant association between intestinal helminth infections and lepromatous leprosy [odds ratio (OR), 10 center dot 88; confidence interval (CI) 95%: 4 center dot 02-29 center dot 4; P < 0 center dot 001]. We also observed that the frequency of intestinal helminths correlated strongly with the mycobacterial index (r = 0 center dot 982, P < 0 center dot 01). Corroborating with our hypothesis, intracellular levels of interferon-gamma were decreased significantly in leprosy patients co-infected with intestinal helminths when compared to leprosy patients without worms. Conversely, lepromatous leprosy patients with intestinal worms produced higher levels of both interleukin (IL)-4 and IL-10. Our results suggest that a pre-existing infection by intestinal helminths may facilitate the establishment of M. leprae infection or its progression to more severe forms of leprosy.
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