期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 155, 期 3, 页码 423-432出版社
WILEY
DOI: 10.1111/j.1365-2249.2008.03785.x
关键词
cytomegalovirus; immunocompetent; lymphoid subsets; memory cells; NK cells
类别
资金
- Medical Research Council, UK
Cytomegalovirus (CMV) infects most individuals and elicits a strong CMV-specific immune response. We have studied the influence of CMV-seropositivity on the size of lymphoid subsets in healthy donors and demonstrate that the virus substantially modulates the peripheral lymphoid pool. CD8(+) T cell numbers are increased in all CMV-seropositive individuals because of a striking 60% increment in the CD8(+) T cell memory pool. The CD45RA(+) resting memory pool is doubled after CMV infection and increases further with age. The magnitude of the naive CD8(+) T cell pool is dramatically reduced in CMV-seropositive individuals at all ages, and this accelerates the physiological decline by approximately 40 years. The number of CD4(+) effector memory T cells is increased in CMV-seropositive individuals and is differentially accommodated by a reduction in the number of naive and central memory CD4(+) T cells in young and elderly donors respectively. CMV-seropositivity also increases the total number of B cells in older donors and suppresses the number of CD5(+) B cells. These data reveal that CMV has a profound influence on the immune system of all healthy individuals and add to growing concern regarding the clinical and immunomodulatory significance of CMV infection in healthy donors.
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