期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 158, 期 3, 页码 272-280出版社
WILEY
DOI: 10.1111/j.1365-2249.2009.04033.x
关键词
inflammation; inflammatory bowel disease; MAP kinase
类别
资金
- Fonden til L gevidenskabens Fremme
- Augustinus Foundation
- Aase and Ejnar Danielsens Foundation
- Danish Research Agency
- Ministry of Science, Technology and Innovation [22-04-0622]
Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
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