期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 34, 期 6, 页码 389-396出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641963.2011.649932
关键词
angiotensin-converting enzyme; angiotensins; hypertension; chronic kidney disease
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [02/02920-5, 02/13290-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [02/13290-2] Funding Source: FAPESP
Local activation of the renin-angiotensin system (RAS) has been implicated in the pathogenesis of several renal disorders. In this study we investigated how chronic kidney disease (CKD) modulates RAS components in an experimental model. Male Wistar rats were divided into three groups: sham, nephrectomized, and nephrectomized receiving losartan. Chronic kidney disease animals presented decreased renal N-domain angiotensin-converting enzyme (ACE) activity but overexpression of N-domain ACE in urine. Remnant kidneys presented high angiotensin II levels. Losartan treatment increased urine and tissue ACE activity and tissue levels of angiotensins, mainly angiotensin (1-7), and improved renal and histopathologic parameters. Taken together, the authors' results indicate that pathophysiological changes due to CKD could lead to an increased expression of somatic and N-domain ACE, mainly the 65 kDa isoform, suggesting that this enzyme could be used as a biological urinary marker in CKD.
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