期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 32, 期 3, 页码 179-183出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641960903254505
关键词
apelin; asymetric dymethyl arginine (ADMA); essential hypertension
资金
- GATA Research Center [AR-2004/86]
Both apelin and asymetric dymethyl arginine (ADMA) regulate blood pressures. Low apelin and high ADMA levels have been reported in several cardiometabolic disorders. However, there is no data about ADMA and apelin levels in essential hypertension and any relationship between them. We investigated a group of newly diagnosed and untreated 30 young hypertensive men and 30 healthy controls. Apelin levels were significantly lower and the ADMA levels were significantly higher in the patients (p = 0.04 for both). Both ADMA and apelin were related to the systolic blood pressures (SBP) (beta = -0.393, p = 0.003; beta = 0.285, p = 0.03, respectively). Future studies are necessary in order to clearly define the role of ADMA and apelin in the pathogenesis of essential hypertension.
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