期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 32, 期 1, 页码 43-48出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641960902993053
关键词
-
资金
- Key Science and Technology Program of Heilongjiang Province, China [WB08B09]
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and has been implicated in endothelial dysfunction. We sought to assess weather inflammation is involved in the impaired vascular reactivity induced by ADMA in essential hypertension. Brachial artery flow-mediated dilation (FMD), serum ADMA, and C-reactive protein were determined in 71 never-treated hypertensive patients. Serum ADMA was related directly to C-reactive protein and reversely to FMD. In multiple regression analysis, ADMA was the only independent determinant of FMD. Probably, the chronic inflammation documented in these patients may be considered the mechanistic link between ADMA and vascular damage.
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