期刊
CLINICAL AND EXPERIMENTAL HYPERTENSION
卷 32, 期 7, 页码 453-457出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641961003686443
关键词
tungstate; vanadyl; fructose; prostanoids; triglycerides
资金
- Secretaria de Ciencia y Tecnica of the Universidad de Buenos Aires [B 106]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [5497/05]
This study analyzes the effects of sodium tungstate and vanadyl sulphate in the fructose-overloaded rat, a model of metabolic syndrome. Fructose (9 weeks) increased blood pressure, triglycerydemia, glycemia, and reduced release of vasodilator prostaglandins (prostacyclin and prostaglandin E2) in the mesenteric vascular bed. Sodium tungstate prevented those alterations; meanwhile vanadyl sulfate only prevented the increase in glycemia. In conclusion, the present experiments showed that sodium tungstate is more effective than vanadyl sulfate for the treatment of experimental metabolic syndrome in rats.
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