期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 43, 期 6, 页码 633-641出版社
WILEY
DOI: 10.1111/cea.12095
关键词
asthma; atopy; children; latent class analysis; sensitization; skin prick test
资金
- National Health and Medical Research Council of Australia
Background Atopy in early life is heterogeneous in timing of onset, remission and persistence and in the nature of specific sensitization to allergens. However, this heterogeneity is not well characterized. Objective Our aim was to define longitudinal phenotypes of atopy between ages 1.5 and 8years, and to assess the relationship of the atopy phenotypes to the risk of asthma, eczema and rhinitis at 8years of age. Methods We used latent class analysis (LCA) to define atopy phenotypes using data from skin prick tests that were performed at 1.5, 3, 5 and 8years in participants in the Childhood Asthma Prevention Study (CAPS). Results Four phenotypes were defined: late mixed inhalant sensitization; mixed food and inhalant sensitization; house dust mite (HDM) monosensitized; and no atopy. All three atopic phenotypes were associated with asthma, eczema and rhinitis, but the strongest association, particularly for asthma, was with the mixed food and inhalant sensitization phenotype. Conclusion & clinical relevance We have used a LCA model to define atopy phenotypes empirically. The finding of a strong association between the mixed food and inhalant sensitization class and the presence of asthma and poor asthma control at age 8years implies that food sensitization in early life may be of greater significance for subsequent risk of asthma than previously thought.
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