期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 42, 期 6, 页码 817-826出版社
WILEY
DOI: 10.1111/j.1365-2222.2011.03923.x
关键词
adult; allergy; asthma; atopy; childhood; pregnancy; Vitamin D; vitamin D deficiency; vitamin D supplementation
资金
- Deutsche Forschungsgemeinschaft [SCHA 979/3-1]
- Fritz Thyssen Stiftung
In Western countries, the incidence of atopy and allergic diseases is high and further rising. While genetic factors certainly play a role, epigenetic or even nutritional factors might also be important in the pathogenesis of allergies. Vitamin D - the 'sunshine hormone' - exerts profound effects on both adaptive and innate immune functions involved in the development and course of allergic diseases. As also the incidence of vitamin D insufficiency is surprisingly high in the general population, clinical and experimental studies have started to investigate if correcting vitamin D levels [measured as serum 25 hydroxy vitamin D -25(OH) D] is beneficial or even protective in patients with allergies or children at risk. This review highlights current data on the effects of vitamin D on the allergy-mediating immune system and the vitamin D status in atopic patients. Furthermore, the benefits and risks of vitamin D supplementation during pregnancy, childhood and in adults with respect to the development and course of allergic disease are discussed.
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