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Local Polyethylene Glycol in Combination with Chitosan Based Hybrid Nanofiber Conduit Accelerates Transected Peripheral Nerve Regeneration

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JOURNAL OF INVESTIGATIVE SURGERY
卷 29, 期 3, 页码 167-174

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TAYLOR & FRANCIS INC
DOI: 10.3109/08941939.2015.1098758

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peripheral nerve repair; sciatic; polyethylene glycol; chitosan based hybrid nanofiber; local

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Objective: The incapability to promptly improve behavioral function after discontinuation of peripheral nerves is a current problem in clinical practice. Effect of local polyethylene glycol in combination with chitosan-based hybrid nanofiber conduitwas assessed. Study Design: A 10-mm sciatic nerve defect was bridged using a chitosan-based hybrid nanofiber conduit (Chitosan) filled with phosphate-buffered saline. In authograft group (AUTO), a segment of sciatic nerve was transected and reimplanted reversely. In polyethylene glycol-treated group (CHIT/PEG), the conduit was filled with polyethylene glycol solution. The regenerated fibers were studied within 12 weeks after surgery. Results: The behavioral and functional tests confirmed faster recovery of the regenerated axons in PEG-treated group compared to Chitosan group (p<.05). The mean ratios of gastrocnemius muscles weight were measured. There was statistically significant difference between the muscle weight ratios of CHIT/PEG and Chitosan groups (p<.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers were significantly higher in CHIT/PEG than in Chitosan. In immuohistochemistry, the location of reactions to S-100 in CHIT/PEG was clearly more positive than Chitosan group. Conclusion: polyethylene glycol solution when loaded in a chitosan-based hybrid nanofiber conduit resulted in acceleration of functional recovery and quantitative morphometric indices of sciatic nerve.

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