期刊
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
卷 17, 期 5, 页码 502-507出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1076029610375814
关键词
chronic chagas disease; etiopathogenesis; prothrombotic state
资金
- Consejo de Investigaciones dela UNT
- Consejo de Investigaciones Cientificas y Tecnicas (CONICET) dela Republica Argentina
- Fundacion Universidad Carlos III (Madrid - Espana)
Previously, our group showed a prothrombotic state in asymptomatic patients with chronic Chagas disease. The current paper studies the inflammatory status and endothelial function in these patients. Methods: In 40 patients and 40 healthy volunteers, we evaluated prothrombotic state, blood parasitemia (molecular biology: polymerized chain reaction [PCR]-amplification), tissue factor pathway inhibitor antibodies (aTFPI), interleukin 6 (IL-6), and vascular cell adhesion molecule-1 (VCAM-1). Endothelial function was determined by reactive hyperemia (pulse plethysmography). Results: In patients, prothrombin fragment 1 + 2, D-dimer, PAI-1, and fibrinogen were higher. Amplification of 121/122 primers (Trypanosoma cruzi) was positive in 45% of the patients. Patients presented higher values of a TFPI- immunoglobulin G (IgG; P < .05), a TFPI-IgM (P < .001), IL-6 (P = .004), and VCAM-1 (P = .00001). In both groups, endothelial function was preserved. Conclusions: We found that asymptomatic patients with chronic Chagas disease presented a prothrombotic/inflammatory status. The fact that endothelial function is still preserved suggests that prothrombosis and inflammation are primarily implicated in the beginning of cardiovascular damage.
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