期刊
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
卷 16, 期 1, 页码 91-98出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1076029608330474
关键词
hemostasis; acute hypervolemic fluid infusion; hydroxyethyl starch; gelatin; lactated Ringer's solution; thrombelastograph
资金
- Shanghai Science and Technology Development Fund, China [03ZR14046]
Objective: The purpose of this study was to investigate the effects of acute hypervolemic fluid infusion (AHFI) of 6% hydroxyethyl starch (HES) 130/0.4 or 4% succinylated gelatin (GEL) on hemostasis and the possible mechanisms. Methods: Thirty-six gastric cancer patients were randomized to receive AHFI of either HISS, GEL or lactated Ringer's (RL) solution at the rate of 30 mL.kg(-1).h(-1) from 20 minutes before to 40 minutes after induction of general anesthesia. Results: Group HES and GEL had significantly prolonged PT and aPTT, decreased VIII:C and vWF immediately after AHFI. Statistically prolonged reaction time and coagulation time, and decreased growth angle were seen immediately after HES infusion. Maximum amplitude decreased significantly in group VIES and GEL immediately after and 4 hours after AHFI. Conclusion: Gelatin reduced Clot quality associated with derangements of fibrin polymerization and HES 130/0.4 delayed initiation of sufficient thrombin generation to convert fibrinogen to fibrin and impaired platelet function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据