期刊
CLINICAL & TRANSLATIONAL ONCOLOGY
卷 15, 期 2, 页码 106-110出版社
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s12094-012-0928-6
关键词
Annexin A3; Cancer; Development; Metastasis; Drug resistance
类别
资金
- National Natural Science Foundation of China [81050010, 81171957]
- Key Laboratory of Department of Education of Liaoning [LS2010050]
Annexin family proteins are a well-known multigene family of Ca2+-regulated phospholipid- and membrane-binding proteins. As one of the annexin family genes/proteins, accumulated researches have begun to reveal that annexin A3 (Anxa3) exhibits important roles in tumor development, metastasis and drug resistance. The summarized research evidences in recent years indicate Anxa3 might specifically functionalize either as a tumor suppressor or as a tumor promoter candidate for different cancers depending on the types of tumor cells and tissues. The up-regulation of Anxa3 was found to be correlated with enhanced drug resistance of ovarian cancer, to promote the developments of colorectal adenocarcinoma and pancreatic carcinoma, and to facilitate the metastases of lung adenocarcinoma and hepatocarcinoma; meanwhile, the decreased Anxa3 expressions was negatively correlated with the developments of prostatic carcinoma and renal carcinoma. It is conceivable that Anxa3 could be regarded as a target for therapeutic intervention and a biological indicator for tumor development, invasion and metastasis as well as for the prognosis of tumor patients.
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