期刊
CLINICAL & TRANSLATIONAL ONCOLOGY
卷 13, 期 4, 页码 215-221出版社
SPRINGER
DOI: 10.1007/s12094-011-0645-6
关键词
Fanconi anaemia; Sporadic cancer; Cross-linkers; PARP inhibitors; Chronic myeloid leukemia; Acute myeloid leukemia; Synthetic lethality
类别
资金
- Ministry of Industry and Energy
- Ministry of Science and Innovation [110-90.1, 2009-07164]
- Ministry of Health (Fondo de Investigaciones Sanitarias, ISCII) [RETICS-RD06/0010/0015]
The dissection of the molecular pathways participating in genetic instability disorders has rendered invaluable information about the mechanisms of cancer pathogenesis and progression, and is offering a unique opportunity to establish targeted anticancer therapies. Fanconi anaemia (FA) is a paradigm of cancer-prone inherited monogenic disorders. Moreover, accumulated evidence indicates that genetic and epigenetic alterations in FA genes can also play an important role in sporadic cancer in the general population. Here, we summarise current progress in the understanding of the molecular biology of FA and review the principal mechanisms accounting for a disrupted FA pathway in sporadic cancer. Additionally, we discuss the impact of these findings in the development of new anticancer therapies, particularly with DNA interstrand crosslinkers and with new inhibitors of the FA and/or alternative DNA repair pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据