期刊
CLINICAL & TRANSLATIONAL ONCOLOGY
卷 11, 期 1, 页码 11-19出版社
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s12094-009-0305-2
关键词
Notch pathway; Cancer stem cells
类别
资金
- Instituto de Salud Carlos III (Spanish Goverment)
- Coru a University Hospital Foundation
A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations encoding for proteins involved in critical signalling pathways for stem cells such as BMP, Notch, Hedgehog and Wnt would allow stem cells to undergo uncontrolled proliferation and form tumours. Taking into account that cancer stem cells (CSCs) would represent the real driving force behind tumour growth and that they may be drug resistant, new agents that target the above signalling pathways could be more effective than current anti-solid tumour therapies. In the present paper we will review the molecular basis of the Notch signalling pathway. Additionally, we will pay attention to their role in adult stem cell self-renewal, and cell fate specification and differentiation, and we will also review evidence that supports their implication in cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据