期刊
CLINICAL & EXPERIMENTAL METASTASIS
卷 26, 期 1, 页码 35-49出版社
SPRINGER
DOI: 10.1007/s10585-008-9209-8
关键词
Collagen cross-linking; Hypoxia; Matrix remodeling; Matrix stiffness; Metastasis; Tumor progression
类别
资金
- DOD BCRP [W81XWH-05-1-330]
- NCI [CA078731]
- DOE [A107165]
- Institute of Cancer Research
- Cancer Research UK
- NATIONAL CANCER INSTITUTE [R01CA078731, T32CA009151] Funding Source: NIH RePORTER
Tumor progression ensues within a three-dimensional microenvironment that consists of cellular and non-cellular components. The extracellular matrix (ECM) and hypoxia are two non-cellular components that potently influence metastasis. ECM remodeling and collagen cross-linking stiffen the tissue stroma to promote transformation, tumor growth, motility and invasion, enhance cancer cell survival, enable metastatic dissemination, and facilitate the establishment of tumor cells at distant sites. Matrix degradation can additionally promote malignant progression and metastasis. Tumor hypoxia is functionally linked to altered stromal-epithelial interactions. Hypoxia additionally induces the expression of pro-migratory, survival and invasion genes, and up-regulates expression of ECM components and modifying enzymes, to enhance tumor progression and metastasis. Synergistic interactions between matrix remodeling and tumor hypoxia influence common mechanisms that maximize tumor progression and cooperate to drive metastasis. Thus, clarifying the molecular pathways by which ECM remodeling and tumor hypoxia intersect to promote tumor progression should identify novel therapeutic targets.
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