Enantioselective ortho-C-H Cross-Coupling of Diarylmethylamines with Organoborons

The commonly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the C-H activation of amines for the first time. An enantioselective ortho-C-H cross-coupling between nosyl-protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono-N-protected amino acid (MPAA) ligands as a promoter.