期刊
CLINICA CHIMICA ACTA
卷 486, 期 -, 页码 395-401出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2017.10.033
关键词
Thoracic aortic dissection; Interleukin-22; Inflammation
资金
- National Natural Science Foundation of China [81360055, 81170208, 81560085, 81460081]
Background: Interleukin (IL)-22 plays important roles in the development of arterial disease, including atherosclerosis and hypertension. However, the relationship between IL-22 and acute thoracic aortic dissection (TAD) remains unknown. Methods: Blood samples were collected from patients with chest pain who underwent computed tomography angiography of the thoracic aorta but had no known preoperative diagnosis of coronary artery disease, peripheral artery disease, arthritis, and/or membranous nephropathy. Patients were divided into non-AD (NAD) and TAD groups, and the plasma concentrations of IL-22, IL-6 and tumor necrosis factor (TNF)-alpha were measured. In addition, aortic tissue samples from acute TAD patients and normal donors were collected, and the expression levels of IL-22 and IL-22 receptor 1 (IL-22R1) were measured. Results: IL-22, IL-6 and TNF-alpha levels were significantly higher in acute TAD patients than in NAD patients (IL-22, NAD group: 27.0 (19.1, 38.6) pg/ml vs. TAD group: 32.9 (20.6, 58.3) pg/ml, p < 0.0001). The correlation analysis showed that IL-22 levels were positively correlated with levels of IL-6, TNF-alpha, fasting glucose, blood pressure, white blood cells, C-reactive proteins and D-dimers. Binary logistic regression analyses showed that IL 22 was independently associated with the presence of acute TAD (OR 1.169, 95% CI 1.069 to 1.277; p = 0.001). In addition, compared with aortic tissue of normal controls, TAD aortas showed increased expression of IL-22 and IL-22R1, especially in the torn section (IL-22, non-torn section: 2.8 +/- 0.5/HPF vs. torn section 2.8 +/- 0.5/HPF,p < 0.001). Additionally, macrophage but not T lymphocyte infiltration was significantly increased in the torn section (Macrophage, non-torn section: 2.2 +/- 0.6/HPF vs. torn section 5.7 +/- 1.2/HPF, p < 0.001; T lymphocyte, non-torn section: 2.7 +/- 0.9/HPF vs. torn section 2.4 +/- 0.5/HPF, p = 0.28), as evidenced by increased positive staining for the macrophage marker CD68, as opposed to the T cell marker CD3. Conclusion: IL-22 levels may correlate with the presence of acute TAD.
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