Severe preeclampsia: Are hemostatic and inflammatory parameters associated?

Background: Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE. Methods: D-Dimer, PAI-1, IL-8, IL-6, TNF-alpha, and IFN-gamma concentrations were measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women. Results: D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and nonpregnant women. IL-8, IL-6, and IFN-gamma also were higher in women with sPE compared to normotensive pregnant women. However, only IL-6 and IFN-gamma were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-gamma in sPE. Conclusion: D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE. (C) 2013 Elsevier B.V. All rights reserved.