期刊
CLINICA CHIMICA ACTA
卷 417, 期 -, 页码 39-44出版社
ELSEVIER
DOI: 10.1016/j.cca.2012.12.012
关键词
ACTB; Function; Tumor; Cancer
资金
- National Natural Science Foundation of China [81050010, 81171957, 81272186]
- Key Laboratory of the Department of Education of Liaoning [LS2010050]
Beta-actin (ACTB) has traditionally been regarded as an endogenous housekeeping gene and has been widely used as a reference gene/protein in quantifying expression levels in tumors. However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. ACTB is generally found to be up-regulated in the majority of tumor cells and tissues. The abnormal expression and polymerization of ACTB and the resulting changes to the cytoskeleton are revealed to be associated with the invasiveness and metastasis of cancers. The current review explores relevant mechanisms, integrates current understandings, and provides suggestions for future studies of the roles of ACTB in tumors. (c) 2013 Elsevier B.V. All rights reserved.
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