期刊
CLINICA CHIMICA ACTA
卷 413, 期 19-20, 页码 1430-1437出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2012.06.002
关键词
Obesity; HOMA-IR; PTX3; Physical activity; Exercise
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2009-0070217]
- Sports ToTo
- National Research Foundation of Korea [2009-0070217] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04 +/- 0.82 y, BMI: 26.5 +/- 12 kg/m(2)) participated in the study. All participants were housed together and their amount of physical activity (1823.5 +/- 134 kcal/day) and food intake (1882 +/- 68.8 kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r = -.336, p = 0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = -334, p = 0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r = -280, p = 0.035) and HOMA-IR (r = -281, p =.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 +/- 13 vs -1.46 +/- 0.70, p = 0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children. (C) 2012 Published by Elsevier B.V.
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