期刊
CLINICA CHIMICA ACTA
卷 413, 期 1-2, 页码 319-324出版社
ELSEVIER
DOI: 10.1016/j.cca.2011.10.021
关键词
Albuminuria; High-density lipoprotein cholesterol; Triglyceride; Urine albumin to creatinine ratio (UACR)
资金
- Korean Centers for Disease Control and Prevention [2005-E71013-00, 2006-E71002-00, 2007-E71013-00]
Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40 years or more. Albuminuria was defined as a urine albumin/creatinine ratio >= 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (<1.94 in men, <1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (>=.4.98 in men, >= 4.20 in women) were 1.30 (95% Cl: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-239) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40 years or more in KGRC. (C) 2011 Elsevier B.V. All rights reserved.
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