期刊
CLINICA CHIMICA ACTA
卷 400, 期 1-2, 页码 97-102出版社
ELSEVIER
DOI: 10.1016/j.cca.2008.10.021
关键词
Gastric cancer; MicroRNA; miR-106a; Gene diagnosis
资金
- Ningbo Social Development Research [2007C10014]
- Zhejiang Province Research Project [200803020]
- Zhejiang Natural Sciences Foundation [Y207240, Y207244]
- K. C. Wong Magna Fund in Ningbo University
Background: MicroRNAs (miRNAs) play important roles in carcinogenesis. miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood. Methods: The level of miR-106a in 55 gastric carcinoma and 17 non-tumor tissues was quantified by real-time reverse transcriptase-polymerase chain reaction, and the relationship between miR-106a level and clinical and pathological factors was explored. Results: The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P<0.01). The altered expression of miR-106a was confirmed in gastric cancer cell lines. Conclusion: miR-106a may be a potential biomarker in the diagnosis of gastric carcinoma. (C) 2008 Elsevier B.V. All rights reserved.
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