期刊
CLINICA CHIMICA ACTA
卷 389, 期 1-2, 页码 61-66出版社
ELSEVIER
DOI: 10.1016/j.cca.2007.11.023
关键词
esophageal cancer; matrix metalloproteinases; tumor markers
Background: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases associated with tumor progression. it was proved that expression of MMP-9 in human esophageal cancer tissues correlated with stages of the disease. The aim of the present study was to determine potential clinical use of serum MMP-9 as a tumor marker of esophageal cancer. Methods: The study included 89 patients with esophageal cancer and 30 healthy subjects (control group). We assayed serum levels of MMP-9 and classical tumor markers (SCC-Ag and CEA). We defined the prognostic value and diagnostic criteria for the measurands. Results: Serum levels of MMP-9, CEA and SCC-Ag in esophageal cancer (EC) patients were statistically higher than in the control group. MMP-9 serum concentrations were associated with clinical stages of EC and tumor size. The diagnostic sensitivity of MMP-9 (70%) was higher than tumor markers and increased in combination with SCC-Ag (92%). The area under the ROC curve for MMP-9 (0.733) was lower than for SCC-Ag (0.811) and higher than for CEA (0.673). In Cox's univariate analysis serum MMP-9, SCC-Ag and CEA were not significant for prognosis of EC. Conclusion: The results suggest the usefulness of MMP-9 as a tumor marker in diagnosis, but not in prognosis of esophageal cancer. (C) 2007 Elsevier B.V. All rights reserved.
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