期刊
CLIMACTERIC
卷 15, 期 2, 页码 105-114出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13697137.2011.650656
关键词
REPRODUCTIVE AGING; OVARIAN AGING; MENOPAUSE; FOLLICLE-STIMULATING HORMONE; ANTIMULLERIAN HORMONE; ANTRAL FOLLICLE COUNT; INHIBIN-B
资金
- North American Menopause Society (NAMS)
- National Institute on Aging (NIA)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Endocrine Society
- National Institute on Mental Health (NIMH)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institute on Drug Abuse (NIDA)
- Royal Ottawa Foundation for Mental Health
- Mayo Clinic
- Baycrest
- Northwestern University
- Society for Women's Health Research
- International Menopause Society
- Pfizer
- Australasian Pacific Menopause Society
- Virginia Commonwealth University Institute for Women's Health
- ASRM
- Adcock Ingram
- Servier
- Amgen
- Bayer
- National Institutes of Health (NIH), Department of Health and Human Services (DHHS), through the National Institute on Aging (NIA) [AG039961]
- NIH Office of Research on Women's Health (ORWH)
- American Society for Reproductive Medicine (ASRM)
- International Menopause Society (IMS)
Objective The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. Methods Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimullerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. Results STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage -3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage -1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. Conclusions STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified.
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