期刊
CLIMACTERIC
卷 12, 期 2, 页码 177-184出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13697130802488607
关键词
Microvesicles; Phosphatidylserine; Menopause; Thrombosis; Sex Hormone
资金
- Kronos Longevity Research Institute, NHLBI [HL78638, HL090639]
- American Heart Association [AHA30503Z]
- The Mayo Foundation for Medical Education and Research
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL090639, R01HL078638] Funding Source: NIH RePORTER
Background Estrogen modulates antithrombotic characteristics of the vascular endothelium and the interaction of blood elements with the vascular surface. A marker of these modulatory activities is formation of cell-specific microparticles. This study examined the relationship between blood-borne microparticles and endogenous estrogen at menopause. Methods Platelet activation and plasma microparticles were characterized from women being screened (n=146) for the Kronos Early Estrogen Prevention Study. Women were grouped according to serum estrogen (20pg/ml; low estrogen, n=21 or40pg/ml; high estrogen, n=11). Results Age, body mass index, blood pressure and blood chemistries were the same in both groups. No woman was hypertensive, diabetic or a current smoker. Platelet counts, basal and activated expression of P-selectin on platelet membranes were the same, but activated expression of glycoprotein IIb/IIIa was greater in the high-estrogen group. Numbers of endothelium-, platelet-, monocyte- and granulocyte-derived microparticles were greater in the low-estrogen group. Of the total numbers of microparticles, those positive for phosphatidylserine and tissue factor were also greater in the low-estrogen group. Conclusion These results suggest that, with declines in endogenous estrogen at menopause, numbers of procoagulant microparticles increase and thus may provide a means to explore mechanisms for cardiovascular risk development in newly menopausal women.
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