期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 4, 页码 1535-1539出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508709
关键词
cyclic peptides; integrin inhibitors; molecular imaging; subtype selectivity; alpha v beta 6 integrin
资金
- Deutsche Forschungsgemeinschaft [Ke 147/42-1]
The alpha v beta 6 integrin binds the RGD-containing peptide of the foot and mouth disease virus with high selectivity. In this study, the long binding helix of this ligand was downsized to an enzymatically stable cyclic peptide endowed with sub-nanomolar binding affinity toward the avb6 receptor and remarkable selectivity against other integrins. Computational studies were performed to disclose the molecular bases underlying the high binding affinity and receptor subtype selectivity of this peptide. Finally, the utility of the ligand for use in biomedical studies was also demonstrated here.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据