期刊
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
卷 3, 期 1, 页码 98-U145出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCOUTCOMES.109.875658
关键词
efficiency; likelihood-based approach; missingness mechanism; nonresponse bias; weighting
资金
- National Cancer Institute [U01-CA93344]
- NATIONAL CANCER INSTITUTE [U01CA093344] Funding Source: NIH RePORTER
Missing data are a pervasive problem in health investigations. We describe some background of missing data analysis and criticize ad hoc methods that are prone to serious problems. We then focus on multiple imputation, in which missing cases are first filled in by several sets of plausible values to create multiple completed datasets, then standard complete-data procedures are applied to each completed dataset, and finally the multiple sets of results are combined to yield a single inference. We introduce the basic concepts and general methodology and provide some guidance for application. For illustration, we use a study assessing the effect of cardiovascular diseases on hospice discussion for late stage lung cancer patients. (Circ Cardiovasc Qual Outcomes. 2010; 3: 98-105.)
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