期刊
CIRCULATION-CARDIOVASCULAR IMAGING
卷 7, 期 4, 页码 619-628出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCIMAGING.113.001193
关键词
coronary artery disease; interleukin-1; interleukin-1 receptor antagonist protein; oxidative stress
资金
- Hellenic Cardiology Society
Background-We investigated the effects of anakinra, an interleukin-1 receptor antagonist, on coronary and left ventricular function in coronary artery disease (CAD) patients with rheumatoid arthritis. Methods and Results-In a double-blind crossover trial, 80 patients with rheumatoid arthritis (60 with CAD and 20 without) were randomized to a single injection of anakinra or placebo and after 48 hours to the alternative treatment. At baseline and 3 hours after treatment, we assessed (1) flow-mediated dilation of brachial artery; (2) coronary flow reserve, ejection fraction, systemic arterial compliance, and resistance by echocardiography; (3) left ventricular global longitudinal and circumferential strain, peak twisting, untwisting velocity by speckle tracking; and (4) interleukin-1 beta, nitrotyrosine, malondialdehyde, protein carbonyl, and Fas/Fas ligand levels. At baseline, patients with CAD had 3-fold higher interleukin-1 beta, protein carbonyl, higher nitrotyrosine, malondialdehyde, and Fas/Fas ligand than non-CAD (P<0.05). After anakinra, there was a greater improvement of flow-mediated dilation (57 +/- 4% versus 47 +/- 5%), coronary flow reserve (37 +/- 4% versus 29 +/- 2%), arterial compliance (20 +/- 18% versus 2 +/- 17%), resistance (-11 +/- 19% versus 9 +/- 21%), longitudinal strain (33 +/- 5% versus 18 +/- 2%), circumferential strain (22 +/- 5% versus 13 +/- 5%), peak twisting (30 +/- 5% versus 12 +/- 5%), untwisting velocity (23 +/- 5% versus 13 +/- 5%), ejection fraction (12 +/- 5% versus 0.5 +/- 5%), apoptotic and oxidative markers, and, in particular, of protein carbonyl (35 +/- 20% versus 14 +/- 9%) in CAD than in non-CAD patients (P<0.01). No changes in the examined markers were observed after placebo. Conclusions-Interleukin-1 inhibition causes a greater improvement in endothelial, coronary aortic function in addition to left ventricular myocardial deformation and twisting in rheumatoid arthritis patients with CAD than in those without.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据