期刊
CIRCULATION-CARDIOVASCULAR IMAGING
卷 6, 期 3, 页码 407-414出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCIMAGING.112.000082
关键词
echocardiography; hypertension; MRI; pediatric; prognosis; pulmonary
资金
- Pulmonary Hypertension Association UK [PHA001]
- British Heart Foundation [FS/08/012/24454]
- National Institute of Health Research, United Kingdom [SRF/08/01/018]
- Actelion
- Pfizer
- GlaxoSmithKlein
- Lilly
- Encysive
- GlaxoSmithKline
- British Heart Foundation [PG/11/98/29201, FS/08/012/24454, PG/10/76/28545] Funding Source: researchfish
- National Institute for Health Research [SRF/01/018, ACF-2011-14-016] Funding Source: researchfish
Background-There are very few validated prognostic markers in pediatric pulmonary hypertension. Cardiac MRI is a useful, noninvasive method for determining prognosis in adults. The present study is the first to assess its prognostic value in children. Methods and Results-A total of 100 children with pulmonary hypertension (median, 10.4 years; range, 0.5-17.6 years) were evaluated (idiopathic, n=60; repaired congenital heart disease, n=22; miscellaneous, n=18). In all patients, ventricular volumes and great vessel flow were measured. Volumetric data were obtained using retrospectively gated cine imaging (n=37) or real-time imaging (n=63), depending on the patient's ability to hold his or her breath. During a median follow-up of 1.9 years, 11 patients died and 3 received lung transplantation. Of the cardiac MR parameters measured, right ventricular ejection fraction and left ventricular stroke volume index were most strongly predictive of survival on univariate analysis (2.6- and 2.5-fold increase in mortality for every 1-SD decrease, respectively; P<0.05). These results were reflected in good separation of tertile-based Kaplan-Meier survival curves for these variables. Conclusions-Cardiac MR measures correlate with clinical status and prognosis in children with pulmonary hypertension. Cardiac MR is feasible and may be useful in clinical decision making in pediatric pulmonary hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据